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Structural, Conformational and Interactional Investigation of Proteins with Related Sequences and Multiple Structures
Lessandra Eller,
Luiz Rocha
Issue:
Volume 3, Issue 2, June 2018
Pages:
19-29
Received:
18 April 2018
Accepted:
8 May 2018
Published:
1 June 2018
Abstract: Homologous proteins are special macromolecules with related primary sequences and multiple native structures and together with sequence-unrelated nonhomologous ones both constitute the protein amazing universe. Here is made a thorough sample selection, and employed quantitative predictions to analyze structures, conformations, steric and hydrophobic interactions and underlying molecular mechanisms in proteins via two coarse-grained (hydrophobic-polar, large-small) models. First, five empirical relations from nonhomologous samples are determined correlating large and hydrophobic residue sequences from primary to helix and β-sheet structures of functional conformations. When applied to homologous proteins, such empirical relations allow precisely surveying the interaction performance, identifying four types of molecular mechanisms, and computing the stability level in conformation ensembles. 1764 structural inspections capture essential features and furnish structural-interactional insights for homologous proteins, as well as suggest a fruitful way for better understanding conformational variability in biomolecular processes such as protein evolution, dynamics, folding and design.
Abstract: Homologous proteins are special macromolecules with related primary sequences and multiple native structures and together with sequence-unrelated nonhomologous ones both constitute the protein amazing universe. Here is made a thorough sample selection, and employed quantitative predictions to analyze structures, conformations, steric and hydrophobi...
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Cytoarchitecure and Connectivity of the Superior Colliculus in Mouse Brain
Issue:
Volume 3, Issue 2, June 2018
Pages:
30-37
Received:
7 June 2018
Accepted:
26 June 2018
Published:
18 July 2018
Abstract: Superior Colliculus (SC) plays a vital role in visual target selection and attention shifting; it also an important structure in studying the central nervous system. However, the cytoarchitecture and connectivity of the SC in mouse brain have not been explicitly explored. In this paper, to investigate the structural delineations and of connectivity SC, we first delineated the morphology of the SC by Nissl stain, and further explored different genes expressed in the SC. It demonstrates that gene Tpd52l1 is densely expressed in the SC, which helps describe the borders of the SC. In addition, we explore the connectivity of Superior Colliculus (validating the projections from other structures to SC and examining the projections from SC to other structure). The anterograde and retrograde projection circuitries between SC and IC are particularly addressed, which indicates that the SC is involved in the visual, auditory and other somatosensory physiological activities.
Abstract: Superior Colliculus (SC) plays a vital role in visual target selection and attention shifting; it also an important structure in studying the central nervous system. However, the cytoarchitecture and connectivity of the SC in mouse brain have not been explicitly explored. In this paper, to investigate the structural delineations and of connectivity...
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Isotherm Studies of Adsorption of Cr (Vi) Ions onto Coconut Husk
Egwuatu Chinyelu Ijeamaka,
Odebeatu Chinonso Christian,
Obumselu Onyeka Fabian,
Iloamaeke Ifeoma MaryJane,
Kammeje Tochukwu Joseph
Issue:
Volume 3, Issue 2, June 2018
Pages:
38-44
Received:
8 March 2017
Accepted:
20 January 2018
Published:
23 August 2018
Abstract: In this study, the application of ground coconut husk GCH for removal of Cr (VI) from its aqueous solution was investigated. Several batch experiments were carried out with different values of test conditions including sorbent concentration, contact time, temperature and pH. The results obtained showed that adsorption of Cr (VI) followed Freundlich isotherm model. Dubinin-Radushkevich isotherm revealed that adsorption of the three metal ions principally followed chemical adsorption process. Adsorption kinetics was best described by pseudo-second order. Thermodynamic studies revealed that adsorption of Cr (VI) were endothermic process since ∆H was positive. Adsorption of Cr (VI) was spontaneous as evident from the negative value ∆G. Uptake of metal ion from their aqueous solution increases with increase in pH but decreases slightly at pH of 8.
Abstract: In this study, the application of ground coconut husk GCH for removal of Cr (VI) from its aqueous solution was investigated. Several batch experiments were carried out with different values of test conditions including sorbent concentration, contact time, temperature and pH. The results obtained showed that adsorption of Cr (VI) followed Freundlich...
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